AstraZeneca said Monday that the trial, which included 32,000 people, found the shot prevented symptomatic Covid-19 in 79% of people, and was 100% effective in preventing severe disease and hospitalization.
It also filled a glaring data gap in the over 65s age group, showing an efficacy of 80% in symptomatic disease prevention, slightly higher than the average of all age groups. Regulators in several European nations, including France and Germany, had initially advised against using the shot in over 65s, citing a lack of data.
“We are preparing to submit these findings to the US Food and Drug Administration and for the rollout of millions of doses across America should the vaccine be granted US Emergency Use Authorization,” said Mene Pangalos, Executive Vice President, BioPharmaceuticals R&D.
But how swiftly AstraZeneca can deliver on its agreement with the US to supply 300 million doses is unclear. The company is still struggling to make good on its deliveries to the European Union, inflaming tensions between the EU and UK, which have been embroiled in a months-long tussle over a limited supply of doses.
European Commission President Ursula von der Leyen told Germany’s Funke Mediengruppe the EU could block a delivery bound for the UK if AstraZeneca did not meet its delivery targets to the EU first. UK Defense Secretary Ben Wallace slammed her comments as “counterproductive.”
YOU ASKED. WE ANSWERED.
Q: If the AstraZeneca shot doesn’t cause blood clots, why have some people died of clotting after the vaccine?
The regulator could not definitively rule out a possible link between the vaccine and blood clotting related to a very rare condition called Thrombocytopenia — in which a person has a low blood platelet count — including rare cases of clots in the vessels draining blood from the brain (known as CVST).
The EMA stressed that from around 20 million people in the UK and EEA who had received the vaccine as of March 16, it had reviewed only seven cases of blood clots in multiple blood vessels and 18 cases of CVST, making these “rare cases.” A causal link with the vaccine is not proven, but is possible and deserves further analysis, it said.
Blood clots do occur in the general population and during any mass vaccination program, it is normal for some people to experience health issues, like blood clots, for other reasons. Infection with Covid-19 can also cause blood clots, making it difficult to calculate how common these would be in people who have not had the vaccine.
WHAT’S IMPORTANT TODAY
Miami Beach officers shoot pepper balls at spring breakers
The aggressive enforcement actions came just hours after Miami Beach Mayor Dan Gelber declared a state of emergency and set an 8 p.m. curfew, saying the crowds that have descended on the city recently are “more than we can handle.”
The Brazilian town forced to choose who lives and dies
Coronavirus cases are surging in Brazil, and the country’s health systems are increasingly overwhelmed. In nearly every state across Brazil, occupancy rates in intensive care units are at or above 80%. Some of them are at or above 90%, and a few have exceeded 100% occupancy, forcing them to turn patients away.
Covid-19 cases soar in India as second wave takes hold
India imposed a nationwide lockdown a year ago but lifted it after three months. Since then, states have imposed a patchwork of restrictions, many of them relatively relaxed and designed to keep the economy running.
ON OUR RADAR
- The Cat in the Hat, the Very Hungry Caterpillar and … Dr. Anthony Fauci? The country’s top infectious disease expert will be immortalized in a children’s book.
- Benjamin Netanyahu has credited himself with bringing Israel “back to life.” As Israelis head to the polls Tuesday, Now the longtime leader hopes his Covid-19 campaign will save his political future, Hadas Gold writes.
- International spectators will be refused entry into Japan for this summer’s Olympic and Paralympic Games, the Tokyo 2020 Organizing Committee said in a statement on Saturday.
- More than a million passengers have traveled through US airports daily for at least 10 days in a row, official data shows, at a time a dangerous variant is climbing across the country. Experts are split on whether the US will see a new wave.
TODAY’S PODCAST
“The reality is that schools are chronically under-ventilated” — Joseph Allen, director of Harvard University’s Healthy Buildings program
In this episode, Dr. Sanjay Gupta revisits a conversation with Allen about the science behind airborne transmission, as schools and other public buildings begin to reopen. Listen now.